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Ayoub Qanir (M, 37)
Immortal since Oct 10, 2009
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    Valveless Flow Control for Lab-on-a-chip Device

    Harvard ENSC E-155
    Professor Anas Chalah & professor Fawwaz Habbal
    Student: Ayoub Qanir

    April 10th, 2012

    (1) Main Goal of the paper
    What are the design possibilities for valve and valveless-based flow control for lab-on-a-chip devices and what are the manufacturing methods associated therein?
    The paper breaks down various design possibilities of flow cells with valves as well as with valveless-based flow for disposable use that support PCR. The paper also discusses the necessary materials and fabrication methods that would simplify the standard microarray-based analysis and render it cost-effective.

    (2) The Application
    The main application discussed in the paper is DNA testing—The microarray diagnostic testing of genetic sequences from a single sample. The paper also brings up the valveless PCR-microarray based testing used for MRSA identification.

    (3) Strong and Weak Points
    Strong Points
    The paper brings up the faulty maneuvers that could/tend to occur during a standard DNA microarray testing, resulting in contamination of the sample. Therefore the use of sealed integrated devices limits the possibilities of erroneous results. What’s more, the authors discuss the economical and technical advantages of using the sealed lab-on-a-chip devices.
    The paper also discusses many different approaches to fabricating micro valves as well as valveless flow control and how each affect the diagnostic process.
    The authors choose to also describe a new valveless PCR-microarray flow that uses a staircase design and does not need any custom instrumentation used for MRSA identification.
    An example of a flow cell assembly is described (Fig.1) and detailed steps with results are illustrated and discussed
    Cases of imbibtion of liquids from the reaction chamber are discussed and further detailed.
    Advantages of the hydrophilic top film in the analysis are discussed
    Weak points
    The paper fails to illustrate more of the dense data into reader-friendly images hence limiting the digestion and comprehension of the material.

    (4) My Suggestion
    I strongly suggest more illustrations and imagery going hand-in-hand with the progression of the narrative in order for the reader to better assimilate and digest the new material.

    (5) Possible Future Applications
    A cost-effective and fault-proof valveless, sealed integrated devices could come of great use in remote locations. Additionally in developing countries where DNA testing is of essence to contain and limit propagation of malignant infectious agents such as HIV in gabo and Ethiopia.

    (6) My Final Decision
    The study was certainly worth publishing.
    Grant: Approved


    Fri, Apr 27, 2012  Permanent link

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