Subatomic particles do it. Now the observation that groups of brain cells seem to have their own version of quantum entanglement, or "spooky action at a distance", could help explain how our minds combine experiences from many different senses into one memory.
Previous experiments have shown that the electrical activity of neurons in separate parts of the brain can oscillate simultaneously at the same frequency – a process known as phase lockingMovie Camera. The frequency seems to be a signature that marks out neurons working on the same task, allowing them to identify each other.
Dietmar Plenz and Tara Thiagarajan at the National Institute of Mental Health in Bethesda, Maryland, wondered whether more complicated signatures also link groups of neurons. To investigate, they analysed neuronal activity using arrays of electrodes implanted in the brains of two awake macaque monkeys and embedded in dish-grown neuron cultures.
In both cases, the researchers noticed that the voltage of the electrical signal in groups of neurons separated by up to 10 millimetres sometimes rose and fell with exactly the same rhythm. These patterns of activity, dubbed "coherence potentials", often started in one set of neurons, only to be mimicked or "cloned" by others milliseconds later. They were also much more complicated than the simple phase-locked oscillations and always matched each other in amplitude as well as in frequency.
Perfect clones
"The precision with which these new sites pick up on the activity of the initiating group is quite astounding – they are perfect clones," says Plenz.
Importantly, cloned signals only appeared after one region had reached a threshold level of activity. Plenz likens this to the "tipping point" in human societies when a trend becomes adopted by large numbers of people. This threshold might ensure that our attention is only captured by significant stimuli rather than by every single signal.
Since the coherence potentials seemed unique, each one could represent a different memory Plenz suggests. Their purpose may be to trigger activity in the various parts of the brain that store aspects of the same experience. So a smell or taste, say might trigger a coherence potential that then activates the same potential in neurons in the visual part of the brain.
Karl Friston at University College London calls the discovery "a missing piece of the jigsaw puzzle" in terms of brain message transmission.
Journal reference: PLoS Biology, DOI: 10.1371/journal.pbio.1000278
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Word from the authors explains in further detail...
Complex systems, when poised at the transition between order and disorder, exhibit scale-free, power law dynamics. These critical systems are highly adaptive and flexibly process and store information, which for decades prompted the conjecture that the brain might operate at criticality. Our discovery of neuronal avalanches in superficial layers of cortex in 2001 provides solid experimental evidence that indeed the brain might be critical. The spatio-temporal, synchronized activity patterns of avalanches form a scale-free organization that spontaneously emerges in vitro in slice cultures and acute slices and in vivo in the anesthetized rat and in awake macaque monkeys. Avalanches are established at the time of superficial cortex layer differentiation, require balanced fast excitation and inhibition, and are regulated via an inverted-U profile of NMDA/dopamine-D1 interaction, well known from cognitive task paradigms, e.g. working memory. Their internal organization forms a small-world topology that combines local diversity with efficient global communication. Neuronal synchronization in the form of avalanches naturally incorporates gamma-oscillations and cascades, e.g. synfire chains. Cortical networks that display neuronal avalanches optimize their internal information transfer and maximize the range of inputs that can be processed.
Imbedded in the scale-invariant avalanche dynamics, is a threshold-dependent mechanism that allows a local neuronal group, once it reaches a minimal size, to replicate its activity at multiple sites. We named such replication a coherence potential and it can be identified by the identical waveforms found almost simultaneously in the local field potential at many sites. This threshold dependent replication is indicative of a tipping point that bears analogy to the propagation of innovations and economic behavior in social networks, which can spread rapidly once they have garnered a local critical mass.
Overall, our results demonstrate that neuronal avalanches and coherence potentials are signatures of critical network dynamics at which the cortex gains universal properties found at criticality.
http://neuroscience.nih.gov/Lab.asp?Org_ID=117
It has long been thought that memories and behaviors arise from transient propagation of electrical activity among a sub-group of brain cells or neurons forming a 'cell assembly'. My work in Dietmar Plenz's Section on Critical Brain Dynamics led to the discovery 'coherence potentials' that allow identification of transient associations or cell assemblies.
Coherence potentials are complex negative-positive waveforms in the local field potential with durations between 50 and 250 ms that have exceeded a particular amplitude threshold and are therefore able to propagate to a large number of sites in the cortex without distortion of temporal structure or substantial loss of amplitude. The generation of coherence potentials appears to be a general property of the superficial cortex arising from the intrinsic network architecture and cellular properties and thus can be seen in in vitro. Phenomenologically, coherence potentials are like a network level action potential. However unlike action potentials which are stereotypical in shape, coherence potentials have diverse waveforms that are identical within a propagated sequence but distinct between sequences. We believe that the waveform serves for encoding of information as well as an identifier of associations between sites.
http://neuroscience.nih.gov/Fellows/Fellow.asp?People_ID=1643